Anaphylactic reaction to different gonadotropin-releasing hormone agonists for the treatment of endometriosis.
Lüchinger AB, Mijatovic V, Rustemeyer T, Hompes PG
Department of Reproductive Medicine, Endometriosis Center, VU University Medical Center, Amsterdam, The Netherlands.
Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Although skin tests with the replacement goserelin (Zoladex) were negative, usage of this medication resulted in a similar allergic reaction. This is the first case report that shows that, in case of a proven allergy to one GnRH agonist, a switch to another GnRH agonist should not be made even if allergy tests are negative for this medication.
Published 23 February 2011 in Am J Med Sci, 341(3): 240-2.
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